The loss of endothelium-dependent vascular tone control in systemic sclerosis.

ary step in management of large and severe spontaneous pneumothoraces with persistent pleural airleaks. It may help avoid major thoracic surgical procedures and subsequent postoperative morbidity, at least in a group of patients who are not suitable candidates for thoracotomy. Although clinically very useful and an informative study, it raises certain questions in mind that need further clarification.